Development of New Methods

New methods include simultaneous recording of cardiovascular and behavioral signs of pain in awake rats, an algorithm to quantify immunohistochemical staining in dorsal horn after spared nerve injury, simultaneous measurement of action potentials and Ca2+ mobilization in adult spinal cord slices, and a new mouse model of multiple sclerosis to study pain-like behaviors for an extended time course.

Key Publications:

Rahn EJ, Iannitti T, Donahue RR, Taylor BK. Sex differences in a mouse model of multiple sclerosis: neuropathic pain behavior in females but not males and protection from neurological deficits during proestrus. Biol Sex Differ. 5(1):4. (2014) PMID:24581045.

Doolen S, Blake CB, Smith BN, Taylor BK. Peripheral nerve injury increases glutamate-evoked calcium mobilization in adult spinal cord neurons. Mol Pain. 8:56 (2012) PMID:22839304.

Corder G, Siegel A, Intondi AB, Zhang X, Zadina JE, Taylor BK. A novel method to quantify histochemical changes throughout the mediolateral axis of the substantia gelatinosa after spared nerve injury: characterization with TRPV1 and substance P. J Pain. 11(4):388-98 (2010). PMID:20350706

Taylor BK, Peterson MA, Basbaum AI. Persistent cardiovascular and behavioral nociceptive responses to subcutaneous formalin require peripheral nerve input. J Neurosci. 15(11):7575-84. (1995) PMID:7472508.