Projects

MORCA Analgesia and Dependence

Constitutive μ-Opioid Receptor Activity Leads to Long-Term Endogenous Analgesia and Dependence (Corder et al., 2013).

Central Neuropathic Pain in Multiple Sclerosis

Fingolimod reduces cold hypersensitivity in the Experimental Autoimmune Encephalomyelitis (EAE) model of MS (Doolen et al., 2018).

Neuropeptide Y

Excitatory neurons expressing Neuropeptide Y1 receptor (Nelson et al., 2019).

Supraspinal Control of Chronic Pain

Neural activation, measured by Fos expression, in μ-opioid receptor- and PKCδ-expressing neurons in the central nucleus of the amygdala during reinstatement of latent sensitization (Cooper et al., in process).

Collaborations

C3aR1/Iba1 co-expression following nerve injury (Doolen et al., 2017)

Diabetic Neuropathic Pain

Increased stimulus-evoked neuronal activation in the spinal cord of diabetic ZDF rats (Griggs et al., 2016)

Development of new methods

Diagram mapping the path of sensation from the mouse hindpaw through the three branches of the sciatic nerve to the spinal cord dorsal horn, used to generate a new method to precisely quantify changes in protein expression in the mediolateral axis in the Spared Nerve Injury model of neuropathic pain  (Corder et al., 2010)