We are seeking to fill multiple positions to start in late 2018 or early-mid 2019 for PhD or MD/PhDs who are trained in:
- Electrophysiology, interested in using optogenetics to understand how spinal cord circuits adapt to the cellular mechanisms of long-lasting neuronal sensitization
- Neurophysiology, interested in using in vivo calcium imaging to understand the neurobiology of latent pain sensitization in behaving animals
- Neuropharmacology, interested in developing mouse models including self-administration to study supraspinal mechanisms that link pain with endogenous opioid dependence.
We discovered new mechanisms by which the body recruits endogenous GPCR signaling in the CNS to prevent the transition from acute injury to chronic pain by (e.g. Corder et al, Science, 2013). We combine in vivo and slice calcium imaging and optogenetics, together with behavioral neuropharmacology, to validate new protein and cellular targets for the treatment of chronic pain and opioid misuse, and to ultimately generate new non-opioid pharmacotherapies and analgesic drugs for neurotrauma, arthritis, diabetes, and multiple sclerosis. For more details on our work and the specifics of each of the above positions, please see our laboratory web pages https://www.taylorlab.anes.pitt.edu/
Our group recently moved to the University of Pittsburgh School of Medicine, which currently ranks 5th amongst NIH-funded academic medical centers. We are thrilled to launch an Opioid Research Center and to occupy space that is contiguous with 6 of the 7 other core NIH-funded faculty members who make up the Pittsburgh Center for Pain Research http://pcpr.pitt.edu/
The Taylor Lab @ Pitt provides a dynamic research environment with exceptional resources for training in basic and translational neuroscience, including scientific mentorship and collaboration within the PCPR, and access to state-of-the-art core facilities within Pitt. Together, we will design experiments that incorporate your existing and emerging strengths in an environment that values hard work, intellectual curiosity, innovative thinking and teamwork. For more details on training opportunities in pain research such as journal clubs, courses, and seminars, please see http://pcpr.pitt.edu/
Postdoctoral applicants must have a PhD in neuroscience, physiology, pharmacology or equivalent and 3 first-authored research articles in well-known international journals. Current graduate students with planned defense dates in 2018 or early 2019 are particularly encouraged to apply.
Interested candidates may forward their Cover Letter that briefly details career goals and prior research experience, CV, and names of 3 references to Dr. Bradley Taylor via email TaylorLab.email@example.com.
Assistant Research Professor
In addition to the qualifications noted above for the Postdoctoral Fellows, the successful candidate will have published 5 first or senior author papers in international journals in the areas of chronic pain research, opioid misuse, or a related field. Also required is a demonstration of strong writing skills, preferably with a proven track record of independent NIH R-grant funding as Principal Investigator.
Mouse Core Director (Research Associate III-IV)
Requirements include a Bachelor’s in molecular biology, biochemistry, neuroscience or related field. Also required is 3 years of experience in basic science research that includes 2 years of experience in transgenic mouse colonies. Strong oral and written communication skills is essential in our team environment. High-level mouse transgenic colony management experience and organizational skills are also required, with the ability to budget time and manage multiple tasks simultaneously, while closely following IACUC regulations. Proven expertise in troubleshooting unexpected problems with animal breeding, animal health, DNA purification, PCR cycling, and gel electrophoresis is essential. Preferred Qualifications include demonstrable expertise in immunohistochemistry or in situ hybridization of CNS tissue slices and proficiency in rodent anesthesia, surgery, and postoperative care. Applications will be accepted through University of Pittsburgh Human Resources, https://www.pittsource.com/
Clinical Research Coordinator
We are seeking a Clinical Research Coordinator to start in early 2019. The primary work is to manage a research program that studies endogenous opioid analgesia and develops new pharmacotherapeutic approaches to treat pain. The incumbent will collaborate with clinical investigators and basic science research staff to support the activities of the Opiate Research Center at the University of Pittsburgh. This position:
– Identifies, screens, and enrolls participants in research studies in Anesthesiology
– Ensures the collection of data including pain scores and obtains clinical and biologic specimens
– Processes subject payments using the university’s WePay system
– Prepares, submits, and maintains files for IRB proposals and consent forms for research projects.
– Co-manages a mixed clinical/basic science laboratory including develop and maintain system to track research data, manuscripts and publications.
– Maintain all necessary records and documentation
– Maintains close working relationships with the physicians, nurses, technicians and research staff involved.
-Attends research and clinical staff meetings and other program events as requested
-Responsible for training new staff members on research regulations and administration of all research related measures, and supervises students and interns assisting with research projects
Our group recently moved to the University of Pittsburgh School of Medicine. We investigate the mechanisms through which inflammation or injury produces changes in peripheral nerve, spinal cord and brain, leading to a transition from acute pain to chronic pain. We discovered that people can recruit endogenous opioid receptor signaling to prevent the transition from acute injury to chronic pain (e.g. Pereira et al, PLoS One, 2015). For more details on our work, please see our laboratory web pages https://www.taylorlab.anes.pitt.edu/
Applicants must have an MS or equivalent in a relevant field and 3-5 years’ experience in clinical research. Preferred qualifications include 1 year of experience with experimental models of pain, QST (quantitative sensory testing) of pain thresholds, familiarity with IRB submission process, proficient with intravenous drug infusion, and experience in randomized controlled trial (RCT) research.
Interested candidates may forward their resume that briefly details research experience and names of 3 references to Dr. Bradley Taylor via email TaylorLab.firstname.lastname@example.org
We would like to welcome graduate students from either the Center for Neuroscience at the University of Pittsburgh CNUP or the MSTP graduate programs. If you are interested in the lab, please email me to discuss rotation projects.
Undergraduate student research assistant
Undergraduate students are welcome to apply to the Taylor lab to gain research experience. Please email me at TaylorLab.email@example.com.
For further information on training opportunities, please see our training page.